To die, or not to die: E2F1 never decides by itself during serum starvation

To proliferate, not to proliferate or to die. The liver itself decides as needed.

To die or not to die.

This article presents the author's personal reflections and experiences in providing case management for patients with end-of-life issues. Through case examples and practical guidelines, the reader will gain an insight into dealing with terminal states in the acute care setting. References were drawn from recent literature on the subject, and were the stimulus to this piece.

To Die or Not to Die This Is the Problem

The study presented by Kasisi Agricultural Training Centre (KATC) and the Jesuit Centre for Theological Reflection (JCTR, on-line at http://www.jctr.org.zm/gmos.htm) shows several inconsistencies and is based on dangerous premises. In fact, study’s proposal can jeopardize the lives of the Zambian citizens both on short and long term perspective. We summarize our critique in three points. For ea...

To live or let die – complexity within the E2F1 pathway

The E2F1 transcription factor is a recognized regulator of the cell cycle as well as a potent mediator of DNA damage-induced apoptosis and the checkpoint response. Understanding the diverse and seemingly dichotomous functions of E2F1 activity has been the focus of extensive ongoing research. Although the E2F pathway is frequently deregulated in cancer, the contributions of E2F1 itself to tumori...

To die or not to die? Lessons from lesion mimic mutants

Programmed cell death (PCD) is a ubiquitous genetically regulated process consisting in an activation of finely controlled signaling pathways that lead to cellular suicide. Although some aspects of PCD control appear evolutionary conserved between plants, animals and fungi, the extent of conservation remains controversial. Over the last decades, identification and characterization of several le...